Background: Only data of published study results are available to the scientific community for further use such as informing future research and synthesis of available evidence. If study results are reported selectively, reporting bias and distortion of summarised estimates of effect or harm of treatments can occur. The publication and citation of results of clinical research conducted in Germany was studied.Methods: The protocols of clinical research projects submitted to the research ethics committee of the University of Freiburg in 2000 were (...) analysed. Published full articles in several databases were searched and investigators contacted. Data on study and publication characteristics were extracted from protocols and corresponding publications.Results: 299 study protocols were included. The most frequent study design was randomised controlled trial , followed by uncontrolled studies , laboratory studies and non-randomised studies . 182 were multicentre studies including 97 international collaborations. 152 of 299 had commercial funding and 46 non-commercial funding. 109 of the 225 completed protocols corresponded to at least one full publication ; the publication rate was 48%. 168 of 210 identified publications were cited in articles indexed in the ISI Web of Science. The median was 11 citations per publication .Conclusions: Results of German clinical research projects conducted are largely underreported. Barriers to successful publication need to be identified and appropriate measures taken. Close monitoring of projects until publication and adequate support provided to investigators may help remedy the prevailing underreporting of research. (shrink)

A promise to do some action seems to create a binding obligation to do that action. And yet, paradoxically, an obligation seems not to be a fact that we can create or bring into existence; we can create an obligation only by creating or bringing into existence something else. The only way to avoid the paradox is to show that the act of promising creates something other than an obligation, which nonetheless binds us to perform the action in question. After (...) considering and rejecting various options such as the promisee's expectation and the promisor's resolve, Prichard locates the bindingness of a promise in a prior general promise, which allows the noises we make when promising to generate an obligation to perform the promised action. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Translation and interpretation of selected Hadith on Islamic ethics and coduct.

Probably to most students of Moral Philosophy there comes a time when they feel a vague sense of dissatisfaction with the whole subject. And the sense of dissatisfaction tends to grow rather than to diminish. It is not so much that the positions, and still more the arguments, of particular thinkers seem unconvincing, though this is true. It is rather that the aim of the subject becomes increasingly obscure. "What," it is asked, "are we really going to learn by Moral (...) Philosophy?" "What are books on Moral Philosophy really trying to show, and when their aim is clear, why are they so unconvincing and artificial?" And again: "Why is it so difficult to substitute anything better?" Personally, I have been led by growing dissatisfaction of this kind to wonder whether the reason may not be that the subject, at any rate as usually understood, consists in the attempt to answer an improper question. And in this article, I shall venture to contend that the existence of the whole subject, as usually understood, rests on a mistake, and on a mistake parallel to that on which rests, as I think, the subject usually called the Theory of Knowledge. (shrink)

Concerning the nature of desires that pertain to actions, considers the view that we cannot desire something unless we know or think, first, that it does not exist, and second, that it does not exist now. Finds a core of truth in this, but modifies the formula to claim that ‘we can only desire the existence of that of the existence of which in the past, present, or future, as the case may be, we are uncertain.’ Put more simply, a (...) desire is not a desire for the existence of something, but rather a desire for something to be. It follows from this view that we cannot desire something to be the case when we think that, without a doubt, it will be the case. (shrink)

To the question ‘What does it mean to act or to do something?’, replies that it is not easy to identify a common character in actions. Begins by examining the position of Cook Wilson, who maintains that ‘to do something’ means to originate, cause, or bring into existence, either directly or indirectly, some not yet existing state either in oneself or some other body. Although Prichard agrees that usually action involves causing something, he observes that causing a change is not (...) itself an activity. In moving one's hand, one performs that indefinable mental activity of willing some change. The movement of the hand is the effect of the action, not the action itself, a fact overlooked by thinkers like Locke. Turning to the nature of the desire behind one's willing, Prichard rejects the view that this desire is actually a desire for the change willed. Despite forceful objections, Prichard maintains that this desire is the desire for the willing of that change. (shrink)

On Sikh ethics; includes brief biographies of Sikh religious leaders.

This book offers a Wittgensteinian study of concept possession and of the nature of conceptual investigation in philosophy. It is both an ideal advanced introduction to Wittgenstein's philosophy and an original treatment of some of its most crucial yet least developed regions. The book is written as a Socratic dialogue, which frames the discussion within a backward glance to Plato's Theory of Forms. In so doing it makes a bold claim as to Wittgenstein's place in Western philosophy.

This note is in answer to some criticisms by professor mundle of dobb's work on the above topic. he first presents a general argument, relevant to those criticisms, regarding the physical significance of the fifth dimension. (staff).

In elementary derivations of the quantization of azimuthal angular momentum the eigenfunction is determined to be exp(im φ), which is “oversensitive” to the rotation φ → φ+2π, unlessm is an integer. In a recent paper Kerner examined the classical system of charge and magnetic pole, and expressed Π, a vector constant of motion for the system, in terms of a physical angle ψ, to deduce a remarkable paradox. Kerner pointed out that Π(ψ) is “oversensitive” to ψ → ψ+2π unless a (...) certain charge quantization condition is met. Our explicandum of this paradox highlights the distinction between coordinates in classical and quantum physics. It is shown why the single-valuedness requirement on Π(ψ) is devoid of physical significance. We are finally led to examine the classical analog of the quantum mechanical argument that demonstrates the quantization of magnetic charge, to show that there is “no hope” of a classical quantization condition. (shrink)